Solid-Phase Extraction: Precision Technique for Sample Purification
Solid-Phase Extraction (SPE) is a laboratory technique used to purify and concentrate analytes from complex samples before analysis. It is widely used in pharmaceutical analysis, toxicology, environmental testing, and food safety.
SPE involves passing a liquid sample through a solid adsorbent that selectively retains analytes or impurities. Techniques include normal-phase, reversed-phase, ion exchange, and mixed-mode extraction.
Advantages of SPE:
High purification efficiency
Reduced solvent use
Enhanced detection sensitivity
Compatibility with LC-MS and GC-MS
As analytical demands grow, automation and micro-SPE systems are advancing efficiency and reproducibility.
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